Factor 13 Deficiency: Coagulation Factors Deficiency Treatment

Factor 13 deficiency is also known as fibrin stabilizing factor deficiency. It is a very rare condition, and it is an inherited condition. It is present in both genders.

This disorder of coagulation is present in all the racial groups.

Factor 13 Deficiency

Factor 13 is responsible to form a clot and stabilizing the clotting mechanism. If there is factor 13 deficiency, a clot will develop, but it will not remain stable and break quickly. This will give rise to recurrent bleeding in that person.

Generally the bleeding due to factor 13 deficiency occurs as a result of trauma.

Bleeding after head trauma can be a devastating in some individuals.

Coagulation Factors Deficiency

Women can be vulnerable for spontaneous abortion if the condition is not treated. Factor 13 deficiency can give rise to infertility in men. Bleeding into joints and soft tissue, bleeding through the umbilical cord or prolonged bleeding during circumcision can be seen in early childhood.

Factor 13 Deficiency Diagnosis

Diagnosis is made after a detailed family history, and a normal screening test for coagulation such as clotting time and bleeding time.

The specific test for detecting factor 13 can confirm the diagnosis.

Factor XIII Deficiency Treatment

Treatment for factor 13 deficiency include

  • Transfusing of fresh frozen plasma is used to treat factor X111 deficiency.
    Prophylactic therapy with factor 13 concentrate every 4 weeks will maintain sufficient level of factor 13 in the blood of the patient.
  • In a pregnant woman, the frequency of transfusion is increased as the half life of factor 13 reduces during pregnancy.

Before a surgery, a factor 13 deficient patient should receive the concentrate just before the surgery begins. It will help in proper blood clotting and wound healing mechanism.

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