Bile Acid Sequestrants Side Effects: Bile Acid Binding Resins Prevention

Question: Can one take laxatives to prevent the side effects of bile acid binding resins? Which other side effects are observed? Can these drugs cause vitamin deficiencies?

Bile Acid Binding Resins Drugs Side Effects

Regular use of laxatives can rob the body of nutrients, so laxative pills are best avoided. But there are other effective and safe osmotic agents that can soften stools by retaining water in the intestine. They help to eradicate most of the symptoms of constipation caused by bile acid binding resins if they are taken along with plenty of water.

Bloating and belching, heartburn, nausea and abdominal pain are other complaints are associated with this category of drugs.

If other medications need to be taken, then it should be done so at least one hour before the bile acid binding resin or four hours afterwards because the bile acid binding resins can interfere with the absorption of other medications one takes. The drug can also interfere with the absorption of fat soluble Vitamins A, D, E and K and iron and folic acid. So vitamin supplements need to be taken either along with a meal when one is not taking bile acid lowering drug or four hours after one’s last dose.

When the usual dosages of the bile acid binding resins drugs are taken they are not known to cause vitamin or mineral related problems such as anemia. Vitamin deficiencies especially of fat soluble vitamins are hard to detect and doctors don’t look out for them. So an individual himself should look out for it. Fatigue, bone pain, depression, weakened immunity, easy bruising or bleeding (including nosebleeds), night blindness and dry eyes are the signs of deficiency of these nutrients.

Bile Acid Sequestrants and Triglycerides

When you take a bile acid binding resin, sometimes triglyceride level may rise. The increase may last for a short period, but it persists in some people and may require the use of a second-lipid-lowering drug, such as nicotinic acid to lower triglyceride levels.

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