Norepinephrine Deficiency: Symptoms, Treatment For Low Norepinephrine

Low Norepinephrine Causes

Norepinephrine is a type of hormone and a chemical which is produced by the adrenal glands. It acts as an important neurotransmitter. The function of norepinephrine is to make the system able to act and react, to extreme stressful situation. In circumstances which prompt its immediate requirement, it is also given as a drug.

Before discussing effects of norepinephrine deficiency, let us know how important it is and its use in a SOS situation.

When the blood pressure is very low as in a situation of myocardial infarction, especially in an ICCU, norepinephrine is useful to raise the blood pressure.

Norepinephrine is a catecholamine, a part of sympathetic nervous system which reacts to sudden stress the body is put upon. It aids in respiration by relaxing the breathing muscles, when the body is faced by fight or flight situation. It aids in releasing glucose from its store for the immediate fuel requirement

There is a mutation in the dopamine beta –hydroxylase gene which gives rise to deficiency of norepinephrine. There is a increase in dopamine level in the blood.

Norepinephrine Deficiency Symptoms

Lower norepinephrine symptoms gives rise to:

  • Low blood pressure.
  • Nasal blockage.
  • Droopy eyelids.
  • Reduced muscle tone causing limb rigidity.
  • Ejaculation problem.
  • Intolerance to exercise.
  • Blood vessel disease of the heart.
  • Infant delays to open eyes.

Lack of Norepinephrine Treatment

There is lot for the scientists to understand the reason for norepinephrine deficiency, which is also known as dopamine dehydroxylase deficiency (DBH). In this deficiency mineral corticoids are used by some physicians to balance electrolytes and fluid levels. Adrenergic receptor agonist is used to activate muscles, and arteries.

The most controversial and promising treatment in recent times is DOPS, which can reverse many behavioral effects of DBH deficiency and among them is drooling of eye lids.