IgA Deficiency: Symptoms, Treatment and Test for IgA Immune Deficiency

IgA Deficiencies Symptoms

IgA accounts for 19 percent of the total serum immunoglobulin in human body. It is preferentially secreted into cholostrum, saliva, intestinal juice and respiratory secretions.

IgA deficiency syndrome is due to decrease level of IgA (immunoglobulin A) in the serum of an individual. It is a primary deficiency caused due to some problem in the B lymphocyte of the white blood cells.

The major site of IgA production is the laminae propriae, underlying the mucous membrane of the respiratory tract and the intestine.

IgA plays a major role in protecting an individual against the infections of the mucous membrane lining of the gut and the respiratory tract.

It plays a vital role in defense of the intestine against enteroviruses, e.g. poliomyelitis. In short IgA acts as an antiseptic secretion, over the mucous surface of the body.

IgA Immune Deficiency Causes

IgA deficiency causes many unwanted symptoms of several diseases such as:

  • Malabsorption and steatorrhoea.
  • Sinusitis
  • Otitis media.
  • Pneumonia.
  • Diarrhea.
  • Giardiasis.
  • Amebic colitis.
  • Allergies and asthma.
  • Autoimmune disease.
  • Conjunctivitis.
  • Recurrent upper respiratory tract infections

IgA Deficiency Test and Treatment

To determine IgA antibody deficiency, blood test for IgA antibodies is done. There will be low amount of IgA antibodies while anti bodies of IgM and IgG will be normal.

IGA deficiency treatment: There is no specific treatment for it, but antibiotics will help to curtail the infection when there is IgA deficiency.

A person having this deficiency should take influenza vaccine yearly. Doctors may advise prophylactic measures especially during winter for children.