Gastric Lipase | Deficiency And Function Of Gastric Lipase

What Is Gastric Lipase?

Gastric lipase is an enzyme protein which is acidic in nature. It is secreted by the mucosal lining of the fundus of stomach. The pH value of gastric lipase is between 3.0 and 6.0. Gastric lipase is acidic in nature where as pancreatic lipase is alkaline in nature. Due to its acidic content gastric lipase does not require bile to do its function; where as alkaline lipase requires bile for its enzymatic activity.

Function Of Gastric Lipase

  • The food that we eat contains fats; gastric lipase is an enzyme which breaks down the fats found in our food, to make its digestion easy.
  • Lipase is made up of polypeptide and amino acids; its main function is to break the fats cells and make it available to body cells.
  • Gastric lipase acts on the trigyceride molecules to liberate fatty acids molecules. Fatty acid molecules are easily absorbed by the walls of the intestine and transported to blood.

Gastric Lipase

Gastric lipase is very useful when pancreatic lipase i.e. alkaline lipase is unavailable due to pancreatic disease. It does not let down the entire fat digestion process in absence of alkaline lipase.

Though more research is required, it is believed that gastric lipase disinfects the stomach from the swallowed bacteria present in food.

It may due to its acidic nature.

Gastric Lipase Deficiency

In babies gastric lipase helps to break down milk fat molecules, and permeate easy transportation of fat to the tissue cells.

Gastric lipase secretion is made easy by the presence of gastrin in the plasma.

Deficiency of gastric lipase and pancreatic lipase can give rise to many problems such as heart disease, diabetes, deficiency of fat soluble vitamins such as vitamin A, D and E. This is because its deficiency will adversely affect the fat digestion. This is turn will lead to increase in triglyceride and cholesterol in blood.

4 Comments

  1. Hunt said:

    I am 58 years old and was diagnosed with idiopathic Acute Pancreatitis about 2 months ago, and then again about one week later. I had been having horrible upper left abdominal pain for a couple of months before I was diagnosed with Acute Pancreatitis. However, all my tests to check out the cause of my high lipase, MRCP, HIDA SCAN, small bowel series, blood and stool tests, etc., have shown that everything is fairly normal (increased WBC and RBC) with the exception that my lipase remains around 500. I am wondering what other causes may be responsible as I am still not feeling that great (feel like I am getting over the flu, weakness, sight headache and thirsty all the time).
    I do have diverticulosis, but have never had diverticulitis, and I do have a gastric diverticulum. I was never told that the stomach produces lipase and am wondering if my high lipase could be a result of this diverticulum? Is there a test that can differentiate between the different kinds of lipase? Thanks for any input you might provide.

    June 27, 2012
    Reply
    • PUP said:

      There are two tests to detect pancreatitis, serum lipase and serum Amylase. While rise of Amylase level is more in first 24 hours in acute pancreatitis, lipase level peaks up later and remains for long time. High level of lipase is more useful in late diagnosis of pancreatitis. Rise of lipase may also be associated with certain drugs. You should inform your doctor if you are taking any other medicines. So in short, level of lipase remains for longer time. As for the relation between high level of lipase and diverticulitis I am not too aware about it. You should ask your gastroenterologist regarding it.

      July 18, 2012
      Reply
  2. LP said:

    My tests results show that I have low level of gastric lipase, pepsin and amylase. My HbA1c level is 5.9. This means I am in prediabetic phase. Should I be concerned? What must I do to elevate the level? I do not know for sure if low is good.

    August 9, 2018
    Reply
    • PUP said:

      Lipase, pepsin and amylase are certain enzymes that help in proper functioning of metabolism and digestion. HbA1c is glycosalated hemoglobin which suggests an average your blood sugar level in three months to six months. First of all why was it necessary to do these tests? Did your doctor recommend these tests? Did you suffer from any health problems that lead you to do these tests? What is your age? Lipase, pepsin and amylase are certain enzymes that help in proper functioning of metabolism and digestion. HbA1c is glycosalated hemoglobin which suggests an average your blood sugar level in three months to six months. First of all why was it necessary to do these tests? Did your doctor recommend these tests? Did you suffer from any health problems that lead you to do these tests? What is your age?

      August 12, 2018
      Reply

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.